Mitogen-activated protein kinase



Mitogen-activated protein kinase (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, MAP2K and MAP3K which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. The images on the left and right correspond to one representative MAPK structure, i.e. the rat MAPK1 (1erk).

3D Structures of Mitogen-activated protein kinase
Update June 2011

MAPK1
3i5z, 3i60, 2e14, 2ojg, 2oji, 2ojj, 2ok1, 1wzy, 1tvo – hMAPK1+inhibitor - human

2z7l, 3c9w - rMAPK1+inhibitor – rat

1erk - rMAPK1

1gol - rMAPK1 (mutant)

2gph - rMAPK1 (mutant)+HEPTP (mutant)

2fys - rMAPK1 + KIM peptide

2y4i – raMAPK1+kinase suppressor of RAS 2 – rabbit

3oz6 - MAPK1 - Cryptosporidium parvum

MAPK2
3gok - hMAPK2 kinase domain

2pzy, 2p3g, 2jbo, 2jbp – hMAPK2+inhibitor

3a2c, 3kc3, 3fpm, 3fyj, 3fyk - hMAPK2 kinase domain +inhibitor

3m2w, 3kga, 3ka0 – hMAPK2 kinase domain (mutant)+inhibitor

2oza, 2okr, 2onl – hMAPK2+ hMAPK14

2npt - hMAPK2+ hMAPK5

2erk – rMAPK2

3erk, 4erk – rMAPK2+inhibitor

MAPK3
2zoq – hMAPK3

MAPK6
3fxw, 3fhr – hMAPK3 kinase domain +inhibitor

2i6l – hMAPK6

MAPK7
2qby - MAPK7+Virulence protein

MAPK8
3o17, 2gmx, 2g01 – hMAPK8 (mutant)+JIP1 peptide

[11ukh]], 1uki - jMAPK8 JNK1+JIP1 peptide

3o2m - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole

3elj - hMAPK8+inhibitor

2no3, 2h96 – hMAPK8 (mutant)+inhibitor

MAPK9
3e7o - hMAPK9 (mutant)

3npc – hMAPK9 (mutant)+inhibitor

MAPK10
3kvx, 3fv8, 2waj, 3fi2, 3fi3, 3da6, 2zdt, 2zdu, 3cgf, 3cgo, 2r9s, 2o0u, 2o2u, 2exc, 2b1p, 1pmn, 1pmq, 1pmu, 1pmv – hMAPK10+inhibitor

3ptg - hMAPK10+JIP1 peptide

3g9l, 3g90, 3g9n, 2p33 – hMAPK10 kinase domain+inhibitor

3oxi - hMAPK10 + MAPK8 interacting protein + inhibitor

MAPK11
3gp0 – hMAPK11+inhibitor

3gc8, 3gc9 – hMAPK11 (mutant)+inhibitor

MAPK13
3coi – hMAPK13

MAPK14
3mgy, 3mh0, 3mh1, 3mh2, 3mh3, 3hvc, 3npq, 1wbo, 1r39, 2npq – hMAPK14

3od6, 3ody, 3odz, 3oef, 3p4k, 2fsl, 2fsm, 2fso, 2fst, 1r3c – hMAPK14 (mutant)

3new, 3ocg, 3mvl, 3mvm, 3nnu, 3nnv, 3nnw, 3nnx, 3nww, 3mpt, 3lhj, 3huc, 3itz, 3l8x, 3kf7, 3fi4, 3fkl, 3fkn, 3fko, 3fl4, 3fln, 3flq, 3fls, 3flw, 3fly, 3flz, 3fmh, 3fmj, 3fmk, 3fml, 3flm, 3fln, 3fsf, 3fsk, 3kq7, 3iph, 3hv4, 3hv5, 3hv6, 3hv7, 3k3i, 3hec, 3heg, 3gi3, 3hp2, 3hp5, 3hrb, 3ha8, 3gfe, 3hl7, 3hll, 3gcu, 3fc1, 3dt1, 3e92, 3e93, 3d7z, 3d83, 3ctq, 2puu, 3bx5, 3c5u, 2zaz, 2zb0, 2zb1, 2qd9, 2ewa, 2gfs, 2baj, 2bak, 2bal, 2baq, 1zyj, 1wbn, 1wbs, 1wbt, 1wbv, 1wbw, 1zz2, 1zzl, 1yqj, 1w7h, 1w82, 1w83, 1w84, 1oz1, 1ouk, 1ouy, 1m7q, 1kv1, 1kv2, 1di9, 2rg5, 2rg6, 3bv3, 3bv2, 3fmm, 3fmn, 3lfa, 3mw1 - hMAPK14+inhibitor

3o8t, 3mpa, 3obg, 3o8u, 3o8p, 3obj, 3oc1, 3hub, 3l8s, 3hv3, 3iw5, 3iw6, 3iw7, 3iw8, 3k3j, 3gc7, 3gcp, 3gcq, 3gcs, 3gcv, 3ds6, 2i0h, 1ove, 3lfb, 3lfc, 3lfd, 3lfe, 3lff - hMAPK14 (mutant)+inhibitor

2gtn, 2gtm - mMAPK14+inhibitor

2ghm, 2ghl, 1ywr - mMAPK14 (mutant)+inhibitor

3py3 - mMAPK14 phosphorylated

1yw2 - mMAPK14 (mutant)

1lew - mMAPK14+MEF2A

1lez - mMAPK14+MKK3B

MAPK p38
1wfc - hMAPK p38

1bl6, 1bl7, 1bmk, 1a9u, 1ian – hMAPK p38 (mutant)+inhibitor

1p38 - mMAPK p38 (mutant) - mouse

MAPK FUSS
2f9g, 2b9f – yMAPK FUSS – yeast

2fa2 – yMAPK FUSS (mutant)

2f49 - yMAPK FUSS+STE5 peptide

2b9h, 2b9i - yMAPK FUSS (mutant)+MSG5 peptide

2b9j - yMAPK FUSS (mutant)+FAR1 peptide